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Mutations
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Mutations

作者:Qaulityv11

The ascent leaves a mark on your body. Choose mutations before each run - extra strength, hidden flaws, and combinations the flesh refuses to hold - then climb with those rules for the entire act.

作成日

2026年6月19日

更新日

2026年8月24日

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インストール方法はこちら →

説明

このModの説明文は、作者がNexus Modsに英語で投稿したものです。

Mutations



Transform your runs with Mutations, a Custom Run modifier for Slay the Spire 2 that introduces high-stakes strategic deckbuilding through permanent character alterations.

Also on Steam Workshop for subscribe-and-play install.



Core mechanics


  • The mutation budget: start with 1 point to spend on powerful character buffs. Positives cost. Negatives refund.
  • The risk/reward trade-off: take permanent drawbacks to unlock more budget for stronger or extra buffs. You do not need matching positive and negative counts.
  • Run-long permanence: the mutations you choose stick through every floor, elite, and boss until the run ends.

Key features


  • Custom Run modifier: tailored difficulty and creative builds
  • Synergy creation: combine unique positive traits with crippling constraints
  • Deep replayability: every run is a puzzle of how much handicap your deck can handle for extra power

How to get started


  1. Download the main file. Extract the Sts2Mutations folder into Slay the Spire 2\mods\ (fully restart STS2 after install or update).
  2. Start a Custom Run.
  3. Enable the Mutations modifier.
  4. Select your hero, pick your mutations, and start climbing.

With Infinite Ascent


Install this mod and Infinite Ascent. Enable Infinite Ascent and Infinite Ascent: Mutations. Do not also enable the standalone Mutations modifier.

After Act 4+ act bosses, the Spire rewrites your mutations (1 Gift + 1 Flaw). The first rewrite is required. Later you can decline and keep what you have.

At a glance


  • 111 mutations in the Compendium (95 in the picker for one character, plus other heroes' signatures)
  • Mutations Compendium: press F8 or use the top-bar button during a run (use/win stats)
  • Character-gated picks (Silent: Toxic Gambler; Ironclad: Cleave)
  • Unstable Genome auto-only at 4+ positives or 4+ negatives (hidden random combat mutation each fight)
  • Full localization for STS2 interface languages
  • All characters supported on Custom Run
  • Currently not supported for multiplayer

v0.9.10 (beta) for STS2 public-beta (v0.110.x / v0.111.0). This file is for the public-beta game branch. Game updates may require a mod update.

Links


Steam Workshop | Discord | Patreon

Fan-made mod. Not affiliated with Mega Crit.