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Transform your runs with Mutations, a Custom Run modifier for Slay the Spire 2 that introduces high-stakes strategic deckbuilding through permanent character alterations.
Install this mod and Infinite Ascent. Enable Infinite Ascent and Infinite Ascent: Mutations. Do not also enable the standalone Mutations modifier.
After Act 4+ act bosses, the Spire rewrites your mutations (1 Gift + 1 Flaw). The first rewrite is required. Later you can decline and keep what you have.
v0.9.10 (beta) for STS2 public-beta (v0.110.x / v0.111.0). This file is for the public-beta game branch. Game updates may require a mod update.
Steam Workshop | Discord | Patreon
Fan-made mod. Not affiliated with Mega Crit.
Gameplay
Mutations
von Qaulityv11
The ascent leaves a mark on your body. Choose mutations before each run - extra strength, hidden flaws, and combinations the flesh refuses to hold - then climb with those rules for the entire act.
Erstellt
19. Juni 2026
Aktualisiert
24. Aug. 2026
Beschreibung
Diese Beschreibung wird vom Mod-Autor auf Nexus Mods auf Englisch bereitgestellt.
Mutations
Transform your runs with Mutations, a Custom Run modifier for Slay the Spire 2 that introduces high-stakes strategic deckbuilding through permanent character alterations.
Also on Steam Workshop for subscribe-and-play install.
Core mechanics
- The mutation budget: start with 1 point to spend on powerful character buffs. Positives cost. Negatives refund.
- The risk/reward trade-off: take permanent drawbacks to unlock more budget for stronger or extra buffs. You do not need matching positive and negative counts.
- Run-long permanence: the mutations you choose stick through every floor, elite, and boss until the run ends.
Key features
- Custom Run modifier: tailored difficulty and creative builds
- Synergy creation: combine unique positive traits with crippling constraints
- Deep replayability: every run is a puzzle of how much handicap your deck can handle for extra power
How to get started
- Download the main file. Extract the Sts2Mutations folder into Slay the Spire 2\mods\ (fully restart STS2 after install or update).
- Start a Custom Run.
- Enable the Mutations modifier.
- Select your hero, pick your mutations, and start climbing.
With Infinite Ascent
Install this mod and Infinite Ascent. Enable Infinite Ascent and Infinite Ascent: Mutations. Do not also enable the standalone Mutations modifier.
After Act 4+ act bosses, the Spire rewrites your mutations (1 Gift + 1 Flaw). The first rewrite is required. Later you can decline and keep what you have.
At a glance
- 111 mutations in the Compendium (95 in the picker for one character, plus other heroes' signatures)
- Mutations Compendium: press F8 or use the top-bar button during a run (use/win stats)
- Character-gated picks (Silent: Toxic Gambler; Ironclad: Cleave)
- Unstable Genome auto-only at 4+ positives or 4+ negatives (hidden random combat mutation each fight)
- Full localization for STS2 interface languages
- All characters supported on Custom Run
- Currently not supported for multiplayer
v0.9.10 (beta) for STS2 public-beta (v0.110.x / v0.111.0). This file is for the public-beta game branch. Game updates may require a mod update.
Links
Steam Workshop | Discord | Patreon
Fan-made mod. Not affiliated with Mega Crit.